Lipoatrophy revisited.
Trends Endocrinol Metab
; 11(10): 410-6, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11091118
ABSTRACT
The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus (DM). The loss of adipose tissue can have a genetic, immune, or infectious/drug-associated etiology. Causative mutations have been identified in patients for one form of partial lipoatrophy--Dunnigan-type familial partial lipodystrophy. Experiments using lipoatrophic mice demonstrate that the diabetes results from the lack of fat and that leptin deficiency is a contributing factor. Thiazolidinedione therapy improves metabolic control in lipoatrophic patients; the efficacy of leptin treatment is currently being investigated.
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Base de datos:
MEDLINE
Asunto principal:
Tejido Adiposo
/
Diabetes Mellitus Lipoatrófica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos