Schwann cell-conditioned medium inhibits angiogenesis in vitro and in vivo.
Med Pediatr Oncol
; 35(6): 590-2, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11107124
ABSTRACT
BACKGROUND:
Neuroblastomas are biologically heterogeneous tumors that consist of two main cell populations neuroblastic/ganglionic cells and Schwann cells. The amount of Schwannian stroma strongly impacts prognosis. Low tumor vascularity, localized stage, and favorable outcome are associated with tumors that are Schwannian stroma-rich/stroma-dominant. PROCEDURE To investigate if Schwann cells play a role in inhibiting angiogenesis in neuroblastoma tumors, we examined the ability of human Schwann cell-conditioned medium to affect bFGF- and VEGF-induced endothelial cell proliferation and migration, and in vivo angiogenesis.RESULTS:
Schwann cell-conditioned medium significantly inhibited bFGF- and VEGF-induced endothelial cell proliferation and migration. This effect appears to be specific for endothelial cells as smooth muscle cell and fibroblast proliferation were not inhibited by this medium. Schwann cell-conditioned medium also inhibited in vivo angiogenesis in rat corneal assays.CONCLUSIONS:
Schwann cells produce a potent inhibitor(s) of angiogenesis that may be responsible for the low level of vascularity and more benign clinical behavior of Schwannian stroma-rich/stroma-dominant neuroblastoma tumors. Studies to identify the inhibitor(s) are ongoing.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Células de Schwann
/
Medios de Cultivo Condicionados
/
Neovascularización Patológica
Límite:
Humans
Idioma:
En
Revista:
Med Pediatr Oncol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos