Analysis of exposure-time-response relationships using a spline weight function.
Biometrics
; 56(4): 1105-8, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11129467
ABSTRACT
To examine the time-dependent effects of exposure histories on disease, we estimate a weight function within a generalized linear model. The shape of the weight function, which is modeled as a cubic B-spline, gives information about the impact of exposure increments at different times on disease risk. The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case-control study in Germany.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Fumar
/
Métodos Epidemiológicos
/
Modelos Estadísticos
/
Biometría
/
Exposición por Inhalación
/
Neoplasias Pulmonares
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Biometrics
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania