The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Nat Med
; 7(1): 41-7, 2001 Jan.
Article
en En
| MEDLINE
| ID: mdl-11135614
ABSTRACT
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), the transcription factor target of the anti-diabetic thiazolidinedione (TZD) drugs, is reported to mediate macrophage differentiation and inflammatory responses. Using PPAR-gamma-deficient stem cells, we demonstrate that PPAR-gamma is neither essential for myeloid development, nor for such mature macrophage functions as phagocytosis and inflammatory cytokine production. PPAR-gamma is required for basal expression of CD36, but not for expression of the other major scavenger receptor responsible for uptake of modified lipoproteins, SR-A. In wild-type macrophages, TZD treatment divergently regulated CD36 and class A macrophage-scavenger receptor expression and failed to induce significant cellular cholesterol accumulation, indicating that TZDs may not exacerbate macrophage foam-cell formation.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Diferenciación Celular
/
Colesterol
/
Receptores Citoplasmáticos y Nucleares
/
Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos