Endothelial adherens junctions.
J Investig Dermatol Symp Proc
; 5(1): 10-3, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11147668
ABSTRACT
The principle of the molecular organization of adherens junctions follows a uniform pattern, which is found in epithelial, muscular, neuroneal as well as in endothelial cells and is highly conserved among species. Transmembrane molecules of the cadherin family link to catenins, which anchor the adhesion plaque to the cytoskeleton. The kind of cadherin used in adherens junctions is cell-type specific, vascular endothelial (VE)-cadherin is specific for endothelial cells. The assembly and disassembly of the cadherin/catenin complex is dynamic and regulated by growth factors. The functional status of adherens junctions controls endothelial cell-to-cell adhesion, cell scattering, vessel morphogenesis and has intracellular signaling properties, thereby playing an important role in vasculogenesis and angiogenesis.
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Base de datos:
MEDLINE
Asunto principal:
Piel
/
Uniones Adherentes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Investig Dermatol Symp Proc
Asunto de la revista:
DERMATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Austria