Ca(2+) sensors of L-type Ca(2+) channel.
FEBS Lett
; 487(2): 301-6, 2000 Dec 29.
Article
en En
| MEDLINE
| ID: mdl-11150529
ABSTRACT
Ca(2+)-induced inactivation of L-type Ca(2+) is differentially mediated by two C-terminal motifs of the alpha(1C) subunit, L (1572-1587) and K (1599-1651) implicated for calmodulin binding. We found that motif L is composed of a highly selective Ca(2+) sensor and an adjacent Ca(2+)-independent tethering site for calmodulin. The Ca(2+) sensor contributes to higher Ca(2+) sensitivity of the motif L complex with calmodulin. Since only combined mutation of both sites removes Ca(2+)-dependent current decay, the two-site modulation by Ca(2+) and calmodulin may underlie Ca(2+)-induced inactivation of the channel.
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Base de datos:
MEDLINE
Asunto principal:
Calmodulina
/
Calcio
/
Canales de Calcio Tipo L
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Austria