Enhanced locomotor stimulation by NMDA receptor antagonists in alcohol-sensitive ANT rats.
Pharmacol Biochem Behav
; 67(4): 793-9, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11166070
ABSTRACT
The ability of the antagonists for the N-methyl-D-aspartate (NMDA) type of glutamate receptor to modulate locomotor activity were compared in alcohol-sensitive (or alcohol-nontolerant, ANT) and alcohol-insensitive (or alcohol-tolerant, AT) rat lines. Both rat lines showed altered locomotor activity after acute injections of a competitive antagonist (LY235959), a glycine-site antagonist (L-701,324), or noncompetitive antagonists [MK-801, phencyclidine (PCP), and ketamine] of the NMDA receptor. MK-801 at 0.5 mg/kg caused a strong increase in horizontal activity in both rat lines, the effect being significantly greater in the ANT rats. There was a subpopulation among AT rats that was almost completely unresponsive to MK-801. This insensitivity to MK-801 correlated with the lack of c-fos induction in the retrosplenial and cingulate cortices. Fos immunoreactive cells in these brain regions after MK-801 treatment were more numerous in ANT than AT rats, although c-fos induction in the inferior olivary nucleus was similar in all animals after MK-801. The ANT rats showed greater locomotor stimulation also after ketamine and LY235959, while stimulation induced by PCP and depression induced by L-701,324 did not differ between the rat lines. The data suggest that altered NMDA receptor-mediated processes may correlate with differences in innate alcohol sensitivity in the ANT/AT rat model.
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Base de datos:
MEDLINE
Asunto principal:
Consumo de Bebidas Alcohólicas
/
Maleato de Dizocilpina
/
Receptores de N-Metil-D-Aspartato
/
Antagonistas de Aminoácidos Excitadores
/
Isoquinolinas
/
Actividad Motora
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
2000
Tipo del documento:
Article
País de afiliación:
Finlandia