Antiprothrombin autoantibodies in severe preeclampsia and abortion.
Am J Med
; 110(3): 188-91, 2001 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-11182104
ABSTRACT
PURPOSE:
We examined the levels of autoantibodies against prethrombin-1 and fragment-1 in pregnant women to determine the type of autoantibodies that were associated with severe preeclampsia or spontaneous abortion. SUBJECTS ANDMETHODS:
We measured autoantibodies bound to prothrombin, prethrombin-1, and fragment-1 by using an enzyme-linked immunosorbent assay (ELISA) in 12 healthy nonpregnant women, 36 women with normal pregnancies, 28 pregnant women with severe preeclampsia, and 19 pregnant women who subsequently had spontaneous abortion.RESULTS:
Plasma samples in 10 (36%) of the 28 women with severe preeclampsia and 11 (58%) of the 19 women with spontaneous abortion were positive for antiprothrombin antibodies as compared with 3 (9%) of the 36 women with normal pregancies. All 11 of the positive samples from women who had spontaneous abortions were positive for antiprethrombin-1 antibody, but only 1 was positive for antifragment-1 antibody. The mean (+/- SD) titer of antiprethrombin-1 antibodies in patients with spontaneous abortion (36 +/- 9 U) was higher than that in women with normal pregnancies (10 +/- 4 U; P < 0.01). Antiprethrombin-1 antibody was detected in only 2 women with severe preeclampsia, whereas all 10 women with antiprethrombin antibodies were positive for antifragment-1 antibody. The antifragment-1 antibody titer in patients with severe preeclampsia (49 +/- 15 U) was higher than in women with normal pregnancies (13 +/- 6 U, P < 0.01).CONCLUSIONS:
There is a strong and specific association between various types of antiprothrombin antibodies with severe preeclampsia and spontaneous abortion.
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Base de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Autoanticuerpos
/
Protrombina
/
Aborto Espontáneo
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón