Antibodies against a truncated Staphylococcus aureus fibronectin-binding protein protect against dissemination of infection in the rat.
Vaccine
; 19(25-26): 3376-83, 2001 May 14.
Article
en En
| MEDLINE
| ID: mdl-11348701
ABSTRACT
Staphylococcus aureus bacteraemia (SAB) originating from local infections can lead to severe secondary infections such as endocarditis. The protective effect of antibodies against secondary infections was studied in a rat model, where a local joint infection leads to bacteraemia and endocarditis on damaged aortic valves. In this study, immunizations with a truncated D2-domain of the S. aureus fibronectin-binding protein displayed on a cow-pea mosaic virus (CPMV-D) carrier induced protection against endocarditis (P < 0.05). Opsonization of S. aureus with antibodies raised against CPMV-D stimulated both neutrophil activity and macrophage phagocytosis in vitro. Furthermore, intravenous administration of these antibodies protected mice from weight loss due to SAB.
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Base de datos:
MEDLINE
Asunto principal:
Infecciones Estafilocócicas
/
Staphylococcus aureus
/
Proteínas Bacterianas
/
Proteínas Portadoras
/
Adhesinas Bacterianas
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suecia