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Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.
Lee, C H; Jeong, T S; Choi, Y K; Hyun, B H; Oh, G T; Kim, E H; Kim, J R; Han, J I; Bok, S H.
Afiliación
  • Lee CH; Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-600, Korea.
Biochem Biophys Res Commun ; 284(3): 681-8, 2001 Jun 15.
Article en En | MEDLINE | ID: mdl-11396955
ABSTRACT
The anti-atherogenic effects of the citrus flavonoids, naringin and naringenin, were evaluated in high cholesterol-fed rabbits. At 3 months of age, 30 male New Zealand White (NZW) rabbits were divided into three groups (n = 10 per group). The rabbits were fed a 1% cholesterol diet alone (control group) or a diet supplemented with either 0.1% naringin or 0.05% naringenin for 8 weeks. The plasma lipoprotein levels, total cholesterol, triglyceride, and high-density lipoprotein showed no significant differences in the control and experimental groups. Hepatic acyl-CoAcholesterol acyltransferase (ACAT) activity was slightly low in naringin (5.0%)- and naringenin (15.0%)-fed rabbits, compared to control group. The aortic fatty streak areas were significantly lower in both the naringin (19.2 +/- 5.6%)- and naringenin (18.1 +/- 6.5%)-supplemented groups than in the control group (60.4 +/- 14.0%). The expression levels of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), by semiquantitative RT-PCR analysis of the thoracic aorta, were significantly lower in the flavonoids supplemented groups than in the control group. These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.
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Base de datos: MEDLINE Asunto principal: Aorta / Arteriosclerosis / Flavonoides / Flavanonas / Hígado Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2001 Tipo del documento: Article
Buscar en Google
Base de datos: MEDLINE Asunto principal: Aorta / Arteriosclerosis / Flavonoides / Flavanonas / Hígado Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2001 Tipo del documento: Article