Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial.
Circulation
; 103(24): 2928-34, 2001 Jun 19.
Article
en En
| MEDLINE
| ID: mdl-11413082
ABSTRACT
BACKGROUND:
PTCA of a coronary stenosis without documented ischemia at noninvasive stress testing is often performed, but its benefit is unproven. Coronary pressure-derived fractional flow reserve (FFR) is an invasive index of stenosis severity that is a reliable substitute for noninvasive stress testing. A value of 0.75 identifies stenoses with hemodynamic significance. METHODS ANDRESULTS:
In 325 patients for whom PTCA was planned and who did not have documented ischemia, FFR of the stenosis was measured. If FFR was >0.75, patients were randomly assigned to deferral (deferral group; n=91) or performance (performance group; n=90) of PTCA. If FFR was <0.75, PTCA was performed as planned (reference group; n=144). Clinical follow-up was obtained at 1, 3, 6, 12, and 24 months. Event-free survival was similar between the deferral and performance groups (92% versus 89% at 12 months and 89% versus 83% at 24 months) but was significantly lower in the reference group (80% at 12 months and 78% at 24 months). In addition, the percentage of patients free from angina was similar between the deferral and performance groups (49% versus 50% at 12 months and 70% versus 51% at 24 months) but was significantly higher in the reference group (67% at 12 and 80% at 24 months).CONCLUSIONS:
In patients with a coronary stenosis without evidence of ischemia, coronary pressure-derived FFR identifies those who will benefit from PTCA.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Índice de Severidad de la Enfermedad
/
Angioplastia Coronaria con Balón
/
Circulación Coronaria
/
Enfermedad Coronaria
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Circulation
Año:
2001
Tipo del documento:
Article
País de afiliación:
Países Bajos