Neutrophil-rich anaplastic large cell lymphoma of the skull presenting after head trauma.
Pediatr Dev Pathol
; 4(4): 397-401, 2001.
Article
en En
| MEDLINE
| ID: mdl-11441342
ABSTRACT
The presentation of anaplastic large cell lymphoma in bone is uncommon. We report a case of anaplastic large cell lymphoma of the skull that was diagnosed after head trauma. Biopsy revealed significant destruction of the outer table of the frontal bone. Histopathologically, the initial evaluation suggested osteomyelitis because of a mixed inflammatory infiltrate with large numbers of neutrophils. However, several clusters and individual mononuclear cells were atypical. The tumor cells had large, pleomorphic nuclei; these cells stained positively with antibodies to Ki-1 (CD 30), ALK-1, and EMA. Fluorescence in situ hybridization (FISH) showed rearrangement of the ALK gene, which usually results from the t(2;5) translocation, present in most anaplastic large cell lymphomas. There was no evidence of systemic disease. The patient has tolerated chemotherapy and is free of disease 12 months later.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Craneales
/
Linfoma Anaplásico de Células Grandes
/
Antígeno Ki-1
/
Traumatismos Craneocerebrales
/
Neutrófilos
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Dev Pathol
Asunto de la revista:
PATOLOGIA
/
PEDIATRIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos