Developmental aspects of early pancreatic cancer.
Cancer J
; 7(4): 242-50, 2001.
Article
en En
| MEDLINE
| ID: mdl-11561600
The specific cell of origin responsible for generating pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma remains unknown. During development, epithelial stem cells within embryonic pancreatic epithelium give riseto mature acinar, ductal, and islet elements. Emerging evidence suggests that cells with precursor potential also exist within adult pancreas, resulting in significant developmental plasticity among both endocrine and exocrine cell types. In this review, the contribution of developmental plasticity in initiating pancreatic metaplasia and neoplasia is considered, and evidence supporting a role for epithelial stem cells in pancreatic cancer is discussed.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Transformación Celular Neoplásica
/
Carcinoma Ductal Pancreático
/
Neoplasias Primarias Múltiples
Límite:
Humans
Idioma:
En
Revista:
Cancer J
Asunto de la revista:
NEOPLASIAS
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos