DNA sequence recognition by NF kappa B p50 homodimer: strict and obscure recognition sites in the binding sequence.

Kittaka, A; Takayama, H; Kurihara, M; Horii, C; Tanaka, H; Miyasaka, T; Inoue, J

Kittaka, A; Takayama, H; Kurihara, M; Horii, C; Tanaka, H; Miyasaka, T; Inoue, J.

Afiliación

Kittaka A; Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan.

Nucleosides Nucleotides Nucleic Acids ; 20(4-7): 669-72, 2001.

Article en En | MEDLINE | ID: mdl-11563088

ABSTRACT

ABSTRACT

5-Formyl- and 5-(formylmethyl)-2'-deoxyuridines are introduced into a kappa B site instead of thymidine(s) in order to understand target sequence specificity of NF kappa B. It was found that one thymidine in the kappa B site is particularly important for the sequence specific recognition by NF kappa B.

Asunto(s)

FN-kappa B/genética; FN-kappa B/metabolismo; Secuencia de Bases; Sitios de Unión; Dimerización; Modelos Moleculares; FN-kappa B/química; Subunidad p50 de NF-kappa B; Oligonucleótidos/síntesis química; Oligonucleótidos/metabolismo; Especificidad por Sustrato; Timidina/metabolismo

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Base de datos: MEDLINE Asunto principal: FN-kappa B Tipo de estudio: Prognostic_studies Idioma: En Revista: Nucleosides Nucleotides Nucleic Acids Asunto de la revista: BIOQUIMICA Año: 2001 Tipo del documento: Article País de afiliación: Japón

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