Morphine withdrawal increases expression of GABA(A) receptor epsilon subunit mRNA in locus coeruleus neurons.
Neuroreport
; 12(13): 2981-5, 2001 Sep 17.
Article
en En
| MEDLINE
| ID: mdl-11588615
ABSTRACT
An increase in the activity of brain stem locus coeruleus noradrenergic neurons has been hypothesised to be a major factor accounting for opiate withdrawal symptoms. These neurons are under GABAergic inhibition. Their GABA(A) receptors have unique pharmacological properties, most likely due to the enriched expression of GABA(A) receptor subtypes containing novel epsilon and straight theta subunits. Using in situ hybridisation of cryostat sections, we now report a significant increase in the epsilon subunit mRNA expression after precipitation of opioid withdrawal by naloxone. Similar changes were detected in tyrosine hydroxylase mRNA expression. The results suggest increased formation of unique GABA(A) receptor subtype(s) in the locus coeruleus neurons during increased neuronal activity.
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Base de datos:
MEDLINE
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
ARN Mensajero
/
Locus Coeruleus
/
Expresión Génica
/
Receptores de GABA-A
/
Morfina
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Finlandia