Enhanced absorption of 3-O-methyl-D-glucose through the small intestine of rats administered retinyl palmitate.
Res Commun Mol Pathol Pharmacol
; 107(5-6): 349-60, 2000.
Article
en En
| MEDLINE
| ID: mdl-11589362
ABSTRACT
All-trans retinyl palmitate (RP) (1000 IU/kg body weight) was orally administered to rats for three days. The absorption of 3-O-methyl-D-glucose (3-OMG), which is actively transported by Na+-dependent D-glucose co-transporter (SGLT1), in the small intestine of the control and RP-treated rats was investigated by the in vito everted sac and in situ closed loop of intestine techniques. The absorption of [3H]3-OMG in both experiments of the in vito everted sac and in situ closed loop of intestine significantly increased in the RP-treated rats. AUC(0-120min) obtained from the [3H]3-OMG plasma concentration vs. time curve in the RP-treated rats was significantly larger than that in the control rats. On the other hand, the activity of Na+-K+-adenosinetriphosphatase (ATPase) and the transport rate of D-glucose mediated by Na+-independent facilitative glucose transporter (GLUT2) on the basolateral membrane (BLM) were similar between the control and RP-treated rats. Thus it is suggested that RP treatment of rats enhance the small intestinal absorption of glucose mediated by SGLT1.
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Base de datos:
MEDLINE
Asunto principal:
Vitamina A
/
3-O-Metilglucosa
/
Absorción Intestinal
/
Antioxidantes
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Res Commun Mol Pathol Pharmacol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
FARMACOLOGIA
/
PATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón