Statistical inference of sequence-dependent mutation rates.
Curr Opin Genet Dev
; 11(6): 612-5, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11682302
ABSTRACT
Several lines of research are now converging towards an integrated understanding of mutational mechanisms and their evolutionary implications. Experimentally, crystal structures reveal the effect of sequence context on polymerase fidelity; large-scale sequencing projects generate vast amounts of sequence polymorphism data; and locus-specific databases are being constructed. Computationally, software and analytical tools have been developed to analyze mutational data, to identify mutational hot spots, and to compare the signatures of mutagenic agents.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Estadística como Asunto
/
Análisis de Secuencia de ADN
/
Biología Computacional
/
Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos