[Expression of VEGF and tumor angiogenesis in bladder cancer].
Zhonghua Wai Ke Za Zhi
; 38(1): 34-6, 2000 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-11831983
ABSTRACT
OBJECTIVE:
To evaluate expression of vascular endothelial growth factor (VEGF) and its relation to angiogenesis in bladder cancer.METHODS:
The expression of VEGF by immunohistochemical staining was examined in 68 cases of primary transitional carcinoma (TCC) and 7 subjects with normal urothelium. Microvessel density (MVD) in 40 cases of invasive bladder cancer was determined by Factor VIII immunohistochemical staining.RESULTS:
The expression of VEGF was negative or low level in all normal bladder tissue but high in bladder cancer. VEGF and MVD were closely related to tumor cell nuclear grade and clinical stage. The average MVD was higher in the cases with the high level expression of VEGF, than in those with the low level expression of VEGF.CONCLUSIONS:
This study indicates that VEGF is positively correlated with the occurrence and progression of bladder cancer. VEGF is one of the primary angiogenic factors for bladder cancer, and is able to induce tumor angiogenesis and accelerate tumor growth. Quantification of VEGF may provide a valuable marker for a poorer prognosis of patients.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Factores de Crecimiento Endotelial
/
Linfocinas
/
Péptidos y Proteínas de Señalización Intercelular
/
Neovascularización Patológica
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Wai Ke Za Zhi
Año:
2000
Tipo del documento:
Article
País de afiliación:
China