Effect of human Apo AIV against lipid peroxidation of very low density lipoproteins.
Chem Phys Lipids
; 114(1): 45-54, 2002 Jan.
Article
en En
| MEDLINE
| ID: mdl-11841825
ABSTRACT
Recent studies have demonstrated that Apo AIV exerts a protective effect against atherosclerosis. Moreover, Qin et al. (Am. J. Physiol. 274 (1998) H1836) have demonstrated that Apo AIV, isolated from rat plasma, exerts an inhibitory effect against Cu(2+)-induced lipid peroxidation of intestinal lymph and LDL. The aim of the study was to investigate whether human Apo AIV exerts a protective effect against Cu(2+)-induced lipid peroxidation. Our results demonstrated that human Apo AIV exerted an inhibitory effect against Cu(2+) and AAPH induced lipid peroxidation of VLDL, as shown by the lower increase in the levels of TBARS and conjugated dienes in lipoproteins preincubated with Apo AIV. In addition, the tryptophan (Trp) and probe 2-(dimethylamino)-6-lauroylnaphthalene (Laurdan) fluorescence studies demonstrated that the modifications of spectral properties in both lipoproteins preincubated with Apo AIV were lower with respect to ox-lipoproteins, suggesting that Apo AIV prevents the modification of physico-chemical properties due to peroxidation.
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Base de datos:
MEDLINE
Asunto principal:
Apolipoproteínas A
/
Peroxidación de Lípido
/
Lipoproteínas VLDL
/
2-Naftilamina
Límite:
Humans
Idioma:
En
Revista:
Chem Phys Lipids
Año:
2002
Tipo del documento:
Article
País de afiliación:
Italia