Herpes simplex encephalitis in a domestic rabbit (Oryctolagus cuniculus).
J Comp Pathol
; 126(4): 308-11, 2002 May.
Article
en En
| MEDLINE
| ID: mdl-12056779
An adult domestic rabbit showing neurological signs was subjected to euthanasia. At necropsy, macroscopical lesions were absent. Histopathologically, extensive lesions were seen, particularly in the cerebral cortex. Non-suppurative meningitis was present and there was lymphocytic and plasmacytic perivascular cuffing in the neuropil. The cerebral cortex showed extensive segmental neuronal and glial necrosis. Within the necrotic areas, large amphophilic intranuclear inclusion bodies were present in neurons and glial cells. Immunohistochemically, neurons and glial cells in the affected areas were labelled by polyclonal antibodies against both herpes simplex virus-1 (HSV-1) and HSV-2. The agent was classified as HSV-1 by polymerase chain reaction analysis. This is only the second reported natural case of herpes simplex infection in a rabbit.
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Base de datos:
MEDLINE
Asunto principal:
Conejos
/
Corteza Cerebral
/
Herpesvirus Humano 1
/
Encefalitis por Herpes Simple
Límite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Suiza