Cross-priming is under control of the relB gene.
Scand J Immunol
; 56(3): 219-23, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12193222
ABSTRACT
Cross-priming is an important mechanism of intercell transfer of antigenic material leading to the specific activation of cytotoxic T lymphocytes. Dendritic cells (DCs) are considered the central antigen-presenting cell in cross-priming. Here we decided to probe the role of the relB gene, a regulator of DC differentiation, in the in vivo cross-priming of a model tumour antigen, TAP(-/-) murine embryo cells (MEC), expressing human adenovirus type 5 early region 1. To this end, we used relB(-/-) mutant mice to generate bone marrow (BM) chimeras as these possess few residual DC but are capable of initiating CD4+ and CD8+ T-cell responses in vivo. Our results show that relB(-/-) BM chimeras are unable to cross-prime CD8+ T cells, suggesting that the relB gene regulates cross-priming.
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Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Linfocitos T Citotóxicos
/
Proteínas Proto-Oncogénicas
/
Presentación de Antígeno
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Scand J Immunol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos