Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.
Bioorg Med Chem Lett
; 12(20): 2829-31, 2002 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-12270156
ABSTRACT
The 3'-epi diastereomer of K-252a was synthesized with the goal of evaluating the stereochemical requirements of the 3'-sugar alcohol on kinase inhibitory activity. Inverting the 3'-alcohol resulted in a 20 nM inhibitor of VEGFR2 and a 1 nM inhibitor of TrkA tyrosine kinase.
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Base de datos:
MEDLINE
Asunto principal:
Fosfotransferasas
/
Carbazoles
/
Inhibidores Enzimáticos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos