Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy.
Clin Microbiol Rev
; 16(1): 114-28, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12525428
ABSTRACT
Acyclovir, penciclovir, and their prodrugs have been widely used during the past two decades for the treatment of herpesvirus infections. In spite of the distribution of over 2.3 x 10(6) kg of these nucleoside analogues, the prevalence of acyclovir resistance in herpes simplex virus isolates from immunocompetent hosts has remained stable at approximately 0.3%. In immuncompromised patients, in whom the risk for developing resistance is much greater, the prevalence of resistant virus has also remained stable but at a higher level, typically 4 to 7%. These observations are examined in the light of characteristics of the virus, the drugs, and host factors.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Aciclovir
/
Simplexvirus
/
Farmacorresistencia Viral
/
Herpes Simple
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Microbiol Rev
Asunto de la revista:
MICROBIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido