Lack of association between B19 or V9 erythrovirus infection and ANCA-positive vasculitides: a case-control study.
Rheumatology (Oxford)
; 42(5): 660-4, 2003 May.
Article
en En
| MEDLINE
| ID: mdl-12709542
ABSTRACT
OBJECTIVES:
To examine the potential association of human B19 or V9 erythrovirus infection and onset of ANCA-positive vasculitides.METHODS:
We tested the sera of 13 adults with newly diagnosed ANCA-positive vasculitides. Each was age- and sex-matched to three sera obtained from healthy controls. All samples were tested for B19- and V9-specific immunoglobulin (Ig) G and IgM antibodies (Ab) (third-generation ELISA), and B19 or V9 DNA was sought with the polymerase chain reaction. Statistical analysis was performed by conditional logistic regression.RESULTS:
Patient diagnoses comprised six cases of Wegener's granulomatosis, six of microscopic polyangiitis and one of Churg-Strauss syndrome. IgG Ab to B19 were detected equally in patient and control sera (77 and 79% respectively) (odds ratio=0.84, P=0.84). All 13 cases and 39 controls were negative for IgM Ab and viral DNA.CONCLUSION:
These results suggest that neither acute nor chronic B19 or V9 infection is an aetiological factor in ANCA-associated vasculitides.
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Base de datos:
MEDLINE
Asunto principal:
Vasculitis
/
Infecciones por Parvoviridae
/
Erythrovirus
/
Anticuerpos Anticitoplasma de Neutrófilos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Rheumatology (Oxford)
Asunto de la revista:
REUMATOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia