Therapeutic vaccination for closed head injury.
J Neurotrauma
; 20(6): 559-69, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12906740
ABSTRACT
Closed head injury often has a devastating outcome, partly because the insult, like other injuries to the central nervous system (CNS), triggers self-destructive processes. During studies of the response to other CNS insults, it was unexpectedly discovered that the immune system, if well controlled, provides protection against self-destructive activities. Here we show that in mice with closed head injury, the immune system plays a key role in the spontaneous recovery. Strain-related differences were observed in the ability to harness a T cell-dependent protective mechanism against the effects of the injury. We further show that the trauma-induced deficit could be reduced, both functionally and anatomically, by post-traumatic vaccination with Cop-1, a synthetic copolymer used to treat patients with multiple sclerosis and found (using a different treatment protocol) to effectively counteract the loss of neurons caused by axonal injury or glutamate-induced toxicity. We suggest that a compound such as Cop-1 can be safely developed as a therapeutic vaccine to boost the body's immune repair mechanisms, thereby providing multifactorial protection against the consequences of brain trauma.
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Base de datos:
MEDLINE
Asunto principal:
Vacunación
/
Traumatismos Cerrados de la Cabeza
/
Proteína Coat de Complejo I
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
J Neurotrauma
Asunto de la revista:
NEUROLOGIA
/
TRAUMATOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Israel