Features of skin-coincubated macrophages that promote recovery from spinal cord injury.
J Neuroimmunol
; 142(1-2): 10-6, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-14512160
ABSTRACT
Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.
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Base de datos:
MEDLINE
Asunto principal:
Piel
/
Traumatismos de la Médula Espinal
/
Macrófagos
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Israel