APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.
Neurology
; 62(11): 2116-8, 2004 Jun 08.
Article
en En
| MEDLINE
| ID: mdl-15184629
ABSTRACT
The epsilon4 allele of APOE is a risk factor for Alzheimer disease (AD). By analysis of a large cohort of AD patients (n = 563) and control subjects (n = 118), it is shown that the epsilon4 allele is strongly associated with reduced CSF levels of beta-amyloid (1-42) (Abeta42) in both AD (p < 10(-9)) and control (p = 0.0012) populations. As no associations of APOE variants with other indexes of AD severity were observed, this effect may reflect a fundamental involvement of ApoE in Abeta metabolism.
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Base de datos:
MEDLINE
Asunto principal:
Apolipoproteínas E
/
Fragmentos de Péptidos
/
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurology
Año:
2004
Tipo del documento:
Article
País de afiliación:
Suecia