Amantadine for levodopa-induced choreic dyskinesia in compound heterozygotes for GCH1 mutations.
Mov Disord
; 19(10): 1256-8, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15389992
ABSTRACT
Amantadine suppressed severe levodopa-induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase I deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial effect of amantadine on this type of dyskinesia frequently observed in relatively severe dopamine-deficient metabolic disorders.
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Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Dopaminérgicos
/
Amantadina
/
Levodopa
/
Mutación Puntual
/
Discinesia Inducida por Medicamentos
/
GTP Ciclohidrolasa
/
Antiparkinsonianos
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Mov Disord
Asunto de la revista:
NEUROLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Canadá