Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha.
Nucleosides Nucleotides Nucleic Acids
; 23(8-9): 1367-70, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15571260
ABSTRACT
Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.
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Base de datos:
MEDLINE
Asunto principal:
Timidina Fosforilasa
/
Uridina
/
Regulación hacia Arriba
/
Interferón-alfa
Límite:
Humans
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Países Bajos