Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma.
Br J Ophthalmol
; 89(1): 60-3, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15615748
ABSTRACT
AIM:
To compare the plasma levels of endothelin-1 (ET-1) between patients with primary open angle glaucoma with visual field progression despite normal or normalised intraocular pressure and patients with stabile visual fields in a retrospective study.METHODS:
The progressive group consisted of 16 primary open angle glaucoma patients and the group with stable visual field consisted of 15 patients. After a 30 minute rest in a supine position, venous blood was obtained for ET-1 dosing. Difference in the plasma level of ET-1 between two groups was compared by means of analysis of covariance (ANCOVA), including age, sex, and mean arterial blood pressure as covariates.RESULTS:
ET-1 plasma levels were found to be significantly increased in patients with deteriorating (3.47 (SD 0.75) pg/ml) glaucoma when compared to those with stable (2.59 (SD 0.54) pg/ml) visual fields (p = 0.0007).CONCLUSIONS:
Glaucoma patients with visual field progression in spite of normal or normalised intraocular pressure have been found to have increased plasma endothelin-1 levels. It remains to be determined if this is a secondary phenomenon or whether it may have a role in the progression of glaucomatous damage.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Glaucoma de Ángulo Abierto
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Endotelina-1
Tipo de estudio:
Observational_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Br J Ophthalmol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Suiza