The effects of estradiol on avoidance learning in ovariectomized adult rats.
Integr Physiol Behav Sci
; 39(3): 192-206, 2004.
Article
en En
| MEDLINE
| ID: mdl-15929501
ABSTRACT
The present study examined the effects of ovariectomy and subsequent estradiol replacement on learning in young adult rats using a set of instrumental avoidance paradigms differing in the nature and extent of prior experience in the learning context. Thus, one group of animals was placed directly into avoidance learning (AV). A second group was trained on an appetitive task first, and then transferred into the aversive context (AP-AV). The third group was exposed to the training context without any specific appetitive response requirement, and then required to learn an active avoidance response (Context-AV). We found that estradiol (OVX+E) impaired avoidance acquisition in all cases relative ovariectomized controls (OVX). In contrast, while avoidance learning is improved following appetitive training or context exposure in both OVX+E and OVX animals, the OVX+E animals profit to a greater extent from the appetitive or context experience than do the OVX controls. We suggest that this difference may be due to enhanced attentional processes or improved hippocampal processing of contextual factors. Thus, estradiol negatively influences simple associative avoidance learning in ovariectomized rats, but appears to promote positive transfer.
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Base de datos:
MEDLINE
Asunto principal:
Aprendizaje por Asociación
/
Reacción de Prevención
/
Transferencia de Experiencia en Psicología
/
Estradiol
Límite:
Animals
Idioma:
En
Revista:
Integr Physiol Behav Sci
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos