Role of phosphoinositide 3-kinase in the autophagic death of serum-deprived PC12 cells.
Apoptosis
; 10(5): 1031-41, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-16151638
ABSTRACT
The death of serum-deprived undifferentiated PC12 cells shows both autophagic and apoptotic features. Since it is still controversial whether the autophagy is instrumental in the cell death or a mere epiphenomenon, we tested the effects of inhibiting the autophagy by a variety of phosphoinositide 3-kinase inhibitors, and provided evidence that the autophagy, or a related trafficking event, is indeed instrumental in the cell death. Furthermore, by comparing the effects of PI3-K inhibition and caspase-inhibition on autophagic and apoptotic cellular events, we showed that in this case the autophagic and apoptotic mechanisms mediate cell death by parallel pathways and do not act in series.
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Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Células PC12
/
Medio de Cultivo Libre de Suero
/
Apoptosis
/
Fosfatidilinositol 3-Quinasas
Límite:
Animals
Idioma:
En
Revista:
Apoptosis
Año:
2005
Tipo del documento:
Article
País de afiliación:
Suiza