Stromal cell-derived factor-1 genotype, coreceptor tropism, and HIV type 1 disease progression.
J Infect Dis
; 192(9): 1597-605, 2005 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-16206074
ABSTRACT
This study used a well characterized cohort of human immunodeficiency virus type 1 (HIV-1)-infected hemophiliacs to define the relationship between the SDF1-3'A allele, the plasma HIV-1 coreceptor tropism, and the natural history of HIV-1 disease. Subjects heterozygous or homozygous for the SDF1-3'A allele experienced higher rates of decline in CD4+ T cell counts over time than did those without the allele (P=.009). Moreover, they had an increased risk of progression to acquired immunodeficiency syndrome and death, a relationship that persisted even when baseline plasma HIV-1 RNA levels and CD4+ T cell counts or CCR5 Delta 32 and CCR2-64I genotype were controlled for. This relationship was even stronger in a subgroup of subjects for whom tropism data were available. Subjects with the SDF1-3'A allele were also more likely to have detectable X4-tropic viruses (P=.012), and, when tropism was included in the survival analyses, the effect of the SDF1-3'A allele on disease progression was no longer significant. Therefore, the increased frequency of X4-tropic viruses in subjects carrying the SDF1-3'A allele may explain the observed adverse effect that this allele has on the natural history of HIV-1 disease.
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Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
Receptores CXCR4
/
Quimiocinas CXC
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Child
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos