Cytosolic and nuclear androgen receptors in colorectal adenomas.
Anticancer Res
; 12(3): 705-8, 1992.
Article
en En
| MEDLINE
| ID: mdl-1622127
ABSTRACT
The aim of this study was to verify the presence of androgen receptors (AR) in human colorectal adenomas and in normal adjacent mucosa, and to determine whether there is any difference in AR tissue content between females and males. Our data show higher levels of nuclear AR in normal mucosa than in adenomas (p less than 0.001). A significant difference was also present in males between normal and pathological tissue both in cytosolic (p less than 0.05) and nuclear receptors (p less than 0.01). In female subjects this difference was also evident, but not significant. Our results seem to support the hypothesis of protective effects of androgens in colonic mucosa.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Receptores Androgénicos
/
Adenoma
/
Núcleo Celular
/
Mucosa Intestinal
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia