Studies on the attachment of DNA to silica-coated nanoparticles through a Diels-Alder reaction.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 1075-9, 2005.
Article
en En
| MEDLINE
| ID: mdl-16248095
ABSTRACT
A new method has been investigated for the functionalization of gold nanoparticles with DNA. Silica-coated nanoparticles functionalized with a maleimide have been prepared. These particles are designed to react with modified DNA containing a diene functionality at one end of the molecule. The result would be the formation of a more stable attachment of the DNA to the particle through a Diels-Alder reaction. This covalent attachment would not be susceptible to ligand exchanges, which are known to occur in the conventional DNA functionalization of gold nanoparticles.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Nanoestructuras
/
Biología Molecular
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido