Bell-shaped nuclei dividing by symmetrical and asymmetrical nuclear fission have qualities of stem cells in human colonic embryogenesis and carcinogenesis.
Cancer Genet Cytogenet
; 164(1): 16-24, 2006 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-16364758
ABSTRACT
Large cell nuclei with at least eight distinct morphologies have been discovered throughout the fetal gut (5-7 weeks), colonic adenomas, and adenocarcinomas, five of which are not present in the normal adult colon. The most remarkable nuclear forms are hollow bells, approximately 10-15 microns in height and about 7-10 microns in bell mouth diameter. When encased in tubular syncytia, these bell-shaped structures divide symmetrically by an amitotic nuclear fission process resembling the separation of two paper cups. Seven other nuclear morphotypes emerge from the bell-shaped nuclei within the syncytia by asymmetrical amitotic nuclear fission. Cells containing these differentiated nuclear forms subsequently divide extra-syncytially by mitoses that form clonal populations of cells with identical nuclear morphotypes in embryos, adenomas, adenocarcinomas, and metastases. Cells with bell-shaped nuclei thus appear to be responsible for both net growth and differentiation in the embryonic gut, adenomas, and adenocarcinomas, and fulfill the requirements for post-embryonic stem cells in colon organogenesis and carcinogenesis.
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Base de datos:
MEDLINE
Asunto principal:
Células Madre
/
Núcleo Celular
/
Colon
/
Neoplasias del Colon
Límite:
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos