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Indoleamine-2,3-dioxygenase modulation of allergic immune responses.
Le, Annie V; Broide, David H.
Afiliación
  • Le AV; Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0635, La Jolla, CA 92093, USA.
Curr Allergy Asthma Rep ; 6(1): 27-31, 2006 Feb.
Article en En | MEDLINE | ID: mdl-16476191
Induction of immunologic tolerance is highly desirable in the treatment and prevention of allergy and other immune disease states in which the immune response to foreign or self antigens has become overactive. Indoleamine-2,3-dioxygenase (IDO), an enzyme classically known for its role in the tryptophan degradation pathway, has recently emerged as an important immunomodulator of T-cell function and inducer of tolerance. The induced expression of IDO by dendritic cells may suppress T-cell responses and promote tolerance either through direct effects on T cells (mediated by tryptophan depletion or tryptophan metabolites) or through effects of IDO on the dendritic cell. In addition to the potential role of IDO in promoting tolerance in pregnancy, transplantation, and autoimmunity, its role in modulating allergic responses has more recently been investigated, raising the possibility that IDO and its metabolites may be novel targets for immunomodulation in allergy and asthma.
Asunto(s)
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Base de datos: MEDLINE Asunto principal: Células Dendríticas / Indolamina-Pirrol 2,3,-Dioxigenasa / Hipersensibilidad / Tolerancia Inmunológica Límite: Animals / Humans Idioma: En Revista: Curr Allergy Asthma Rep Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos
Buscar en Google
Base de datos: MEDLINE Asunto principal: Células Dendríticas / Indolamina-Pirrol 2,3,-Dioxigenasa / Hipersensibilidad / Tolerancia Inmunológica Límite: Animals / Humans Idioma: En Revista: Curr Allergy Asthma Rep Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos