Progress in designing nucleic acid structures and fine-tuning their interactions.
Arch Biochem Biophys
; 453(1): 93-100, 2006 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-16516137
ABSTRACT
The prediction of the structure of biological macromolecules at the atomic level and the design of new meta-stable structures and secondary interactions are critical tests of our understanding of the structures and the inter-atomic forces that underlie molecular biology. The capacity to accurately predict and design new structures and interactions will allow us to create nucleic acid sequences that will fold in new and useful ways. Here, we present some results to demonstrate the progress we have made in designing and assembling new nucleic acid structures that will make an increasingly important contribution to biology and medicine. We call the reaction cycle that exemplifies our approach 'A handshake from a hairpin on the way to a double helix.'
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Base de datos:
MEDLINE
Asunto principal:
ADN
/
Diseño de Fármacos
/
Modelos Moleculares
/
Ingeniería Química
/
Modelos Químicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Arch Biochem Biophys
Año:
2006
Tipo del documento:
Article
País de afiliación:
Sudáfrica