[Assessment of human papillomavirus testing on liquid-based Cyto-screen system for women with atypical squamous cells of undetermined significance. Effect of age]. / Evaluation du test de détection des papillomavirus humains en milieu liquide Cyto-screen après diagnostic d'atypies des cellules malpighiennes de signification indéterminée. Effet de l'âge.
Gynecol Obstet Fertil
; 34(4): 312-6, 2006 Apr.
Article
en Fr
| MEDLINE
| ID: mdl-16581283
ABSTRACT
OBJECTIVE:
Analyse the performance of human papillomavirus testing with hybrid capture II on liquid-based CYTO-screen system for women diagnosed with atypical squamous cells of undetermined significance according to the age. PATIENTS ANDMETHODS:
Were included all women diagnosed with atypical squamous cells of undetermined significance for whom human papillomavirus testing was performed and cytological and histological procedures were available over a follow-up period of 6 to 18 months.RESULTS:
Human papillomavirus testing was performed in 3,047 patients, and results were compared to cytological and histological follow-up diagnosis in 1,880 cases (61.7%). The sensitivity for diagnosing cervical intraepithelial neoplasia was 93.3% in women less than 30 of age and 89.7% in women more than 30 of age. Specificity was 44.9% in women less than 30 of age and 64.4% in women more than 30 of age. Likelihood ratios confirmed these results as they show a low discriminatory power in case of positive result specifically in women less than 30 of age but an excellent performance in case of negative result. DISCUSSION ANDCONCLUSION:
The use of human papillomavirus testing after a diagnosis of atypical squamous cells of undetermined significance with the residual material of Cyto-screen system is a possible triage procedure to identify patients needing a colposcopy. Its specificity is better for women over 30.
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Base de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Envejecimiento
/
Enfermedades del Cuello del Útero
/
Citodiagnóstico
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
Fr
Revista:
Gynecol Obstet Fertil
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Francia