Inference of DNA sequences from mechanical unzipping: an ideal-case study.
Phys Rev Lett
; 96(12): 128102, 2006 Mar 31.
Article
en En
| MEDLINE
| ID: mdl-16605962
ABSTRACT
The performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments are investigated. We show that the probability of misprediction decreases exponentially with the amount of collected data. The decay rate is calculated as a function of biochemical parameters (binding free energies), the sequence content, the applied force, the elastic properties of a DNA single strand, and time resolution.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Análisis de Secuencia de ADN
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Phys Rev Lett
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia