Addressable molecular tweezers for DNA-templated coupling reactions.
Nano Lett
; 6(5): 978-83, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16683837
ABSTRACT
Here we report the construction of fully addressable DNA-based molecular tweezers to actuate coupling reactions in a programmable fashion. Three tweezers, each bearing two coupling reactants, are self-assembled on a linear DNA track. A fourth tweezer floating freely in solution can be brought to any one of the tweezers and close them by the addition of a unique pair of "fuel" DNA strands. The coupling reactions happen when the tweezers are closed, and this can be controlled sequentially from one tweezer to another. A molecular device of this kind would not only enable programmable chemical reactions but also allow distance-dependent control of biomolecular interactions.
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Base de datos:
MEDLINE
Asunto principal:
ADN
/
Biología Molecular
/
Ácidos Nucleicos Heterodúplex
Idioma:
En
Revista:
Nano Lett
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos