Liver test abnormalities in multiple sclerosis: findings from placebo-treated patients.
Neurology
; 67(7): 1291-3, 2006 Oct 10.
Article
en En
| MEDLINE
| ID: mdl-17030771
ABSTRACT
The risk of an abnormal liver test in 813 patients with multiple sclerosis or clinically isolated syndrome enrolled in placebo arms of clinical trials was greater than expected for alanine aminotransferase (ALT) (relative risk [RR] 3.7; 95% CI 2.3 to 6.0) and aspartate aminotransferase (AST) (RR 2.2; 95% CI 1.3 to 3.6), although not alkaline phosphatase (AP) or total bilirubin, at first presentation. Abnormal test results were associated with higher body mass index (ALT only), male gender (ALT only), and a relapsing-remitting (vs secondary-progressive) course (ALT and AST only).
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Base de datos:
MEDLINE
Asunto principal:
Medición de Riesgo
/
Hepatopatías
/
Pruebas de Función Hepática
/
Esclerosis Múltiple
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Neurology
Año:
2006
Tipo del documento:
Article
País de afiliación:
Canadá