[Use of cabergoline in persisting Cushing's disease]. / Utilisation de la cabergoline dans la maladie de Cushing non contrôlée.
Ann Endocrinol (Paris)
; 67(4): 353-6, 2006 Sep.
Article
en Fr
| MEDLINE
| ID: mdl-17072242
ABSTRACT
Cabergoline is a dopaminergic agonist with demonstrated efficiency of for the treatment of prolactin-secreting pituitary tumors. It has also been reported effective for patients with hypercortisolism uncontrolled by conventional therapies. We describe the use of cabergoline in three patients with Cushing's disease, one of them presenting a silent ACTH-secreting pituitary tumor. Those patients underwent surgery and only one has been treated with radiation therapy. However persisting hypercortisolism motivated the use of cabergoline. We describe a decrease or a normalization in hypercortisolism; for one of the subjects, tumor growth seemed to be stopped. While cabergoline can induce a suppression of cortisol secretion or a corticotroph tumor shrinkage, the sites of action remain unclear.
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Base de datos:
MEDLINE
Asunto principal:
Hiperfunción de las Glándulas Suprarrenales
/
Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT)
/
Ergolinas
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
Fr
Revista:
Ann Endocrinol (Paris)
Año:
2006
Tipo del documento:
Article