Purinergic nerves mediate the non-nitrergic relaxation of the human ileum in response to electrical field stimulation.
Brain Res Bull
; 71(1-3): 242-4, 2006 Dec 11.
Article
en En
| MEDLINE
| ID: mdl-17113952
ABSTRACT
There has been no direct functional evidence for a purinergic innervation of the human intestinal muscle. In the present study, the relaxant effects of electrical field stimulation (1 or 10 Hz for 20s), ATP, and isoprenaline were studied in organ bath experiments on precontracted circular muscle strips of the human ileum. Non-adrenergic, non-cholinergic relaxations in response to electrical field stimulation in the presence of a nitric oxide synthase inhibitor were significantly reduced by the P(2) purinoceptor antagonists pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS; 50 microM) or suramin (100 microM). A combination of the two antagonists yielded an approximately 70% inhibition at 1 Hz. The relaxant effect of exogenous ATP, but not that of isoprenaline, was inhibited by PPADS+suramin. It is concluded that purinergic nerves (through P(2) purinoceptors) play a mediating role in the non-nitrergic relaxation in the human ileum.
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Base de datos:
MEDLINE
Asunto principal:
Purinas
/
Receptores Purinérgicos P2
/
Sistema Nervioso Entérico
/
Íleon
/
Relajación Muscular
/
Músculo Liso
Límite:
Humans
Idioma:
En
Revista:
Brain Res Bull
Año:
2006
Tipo del documento:
Article
País de afiliación:
Hungria