An evaluation of contemporary hidden Markov model genefinders with a predicted exon taxonomy.
Nucleic Acids Res
; 35(1): 317-24, 2007.
Article
en En
| MEDLINE
| ID: mdl-17170005
ABSTRACT
We present an independent evaluation of six recent hidden Markov model (HMM) genefinders. Each was tested on the new dataset (FSH298), the results of which showed no dramatic improvement over the genefinders tested five years ago. In addition, we introduce a comprehensive taxonomy of predicted exons and classify each resulting exon accordingly. These results are useful in measuring (with finer granularity) the effects of changes in a genefinder. We present an analysis of these results and identify four patterns of inaccuracy common in all HMM-based results.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Exones
/
Cadenas de Markov
/
Análisis de Secuencia de ADN
/
Genes
Tipo de estudio:
Evaluation_studies
/
Health_economic_evaluation
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Nucleic Acids Res
Año:
2007
Tipo del documento:
Article
País de afiliación:
Australia