Intracellular calcium does not directly modulate cardiac pacemaker (if) channels.
Pflugers Arch
; 419(6): 662-4, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1724077
ABSTRACT
A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.
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Base de datos:
MEDLINE
Asunto principal:
Nodo Sinoatrial
/
Calcio
Límite:
Animals
Idioma:
En
Revista:
Pflugers Arch
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia