Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.
Mol Psychiatry
; 12(11): 1011-25, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-17457313
ABSTRACT
Several independent linkage studies have identified chromosome 4p15-p16 as a putative region of susceptibility for bipolar disorder (BP), schizophrenia (SCZ) and related phenotypes. Previously, we identified two subregions (B and D) of the 4p15-p16 region that are shared by three of four 4p-linked families examined. Here, we describe a large-scale association analysis of regions B and D (3.8 and 4.5 Mb, respectively). We selected 408 haplotype-tagging single nucleotide polymorphisms (SNPs) on a block-by-block basis from the International HapMap project and tested them in 368 BP, 386 SCZ and 458 control individuals. Nominal significance thresholds were determined using principal component analysis as implemented in the program SNPSpD. In region B, overlapping SNPs and haplotypes met the region-wide threshold (P
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Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Trastorno Bipolar
/
Cromosomas Humanos Par 4
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mol Psychiatry
Asunto de la revista:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Reino Unido