Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells.
Scand J Rheumatol
; 36(2): 136-9, 2007.
Article
en En
| MEDLINE
| ID: mdl-17476620
ABSTRACT
OBJECTIVE:
To analyse the levels of interleukin-6 (IL-6) in the synovial fluids and sera of patients with osteoarthritis (OA) and to identify the IL-6-secreting cells.METHODS:
Serum, synovial fluid, synovial tissue, and articular cartilage samples were collected from 49 OA patients with end-stage knee or hip OA who underwent joint replacement surgery. Serum and synovial fluid levels of IL-6 were measured by enzyme-linked immunosorbent assay (ELISA) and IL-6-secreting cells were identified by immunohistochemistry.RESULTS:
Eight out of 49 patients (16%) exhibited elevated IL-6 levels in the synovial fluids, averaging at 2022+/-526 pg/mL, while the levels in the rest of the patients averaged at 132+/-19 pg/mL. The sera levels of all patients were comparable in the 10 pg/mL range. Immunohistochemical analyses revealed plasma cells in the synovial lining of the high producers as the source of IL-6.CONCLUSIONS:
Synovial fluid IL-6 levels may help to classify OA patients and may point to a subgroup with a particular impact from their immune system.
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Base de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
/
Líquido Sinovial
/
Membrana Sinovial
/
Osteoartritis de la Cadera
/
Interleucina-6
/
Osteoartritis de la Rodilla
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Scand J Rheumatol
Año:
2007
Tipo del documento:
Article