Application of high-intensity focused ultrasound for umbilical artery occlusion in a rabbit model.
Ultrasound Obstet Gynecol
; 30(1): 47-51, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17492825
ABSTRACT
OBJECTIVES:
To investigate the application of high-intensity focused ultrasound (HIFU) for fetal umbilical artery blood flow occlusion in a rabbit model.METHODS:
A prototype HIFU transducer in combination with an imaging probe with Doppler capability was constructed. Using this transducer, HIFU was applied at 1.4, 2.75 or 5.5 kW/cm(2) through the maternal abdominal skin to the fetal intra-abdominal umbilical arteries of four time-mated Japanese White rabbits (11 fetuses) on gestational day 25. Courses of 5-s HIFU exposure were performed until cessation of umbilical blood flow and cardiac arrest were confirmed by Doppler ultrasonography. Fetal necropsy was performed and exposed lesions were assessed by microscopic histological analysis.RESULTS:
The mean diameter of the fetal umbilical artery was 0.6 +/- 0.2 mm and the mean peak systolic velocity of arterial blood flow was 44.7 +/- 18.5 cm/s. When HIFU was applied at 5.5 kW/cm(2), blood flow was completely occluded within 15 courses. HIFU exposure brought about vacuolar degeneration and destruction of elastic fibers in the tunica media of the artery.CONCLUSIONS:
HIFU can be used to occlude umbilical artery blood flow in fetal rabbits.
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Base de datos:
MEDLINE
Asunto principal:
Arteriopatías Oclusivas
/
Terapia por Ultrasonido
/
Arterias Umbilicales
/
Ultrasonografía Prenatal
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Ultrasound Obstet Gynecol
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
GINECOLOGIA
/
OBSTETRICIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón