Synthesis, characterization, and spectroscopy of model molybdopterin complexes.
J Inorg Biochem
; 101(11-12): 1601-16, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-17765313
ABSTRACT
The preparation and characterization of new model complexes for the molybdenum cofactor are reported. The new models are distinctive for the inclusion of pterin-substituted dithiolene chelates and have the formulation Tp(*)MoX(pterin-R-dithiolene) (Tp(*)=tris(3,5,-dimethylpyrazolyl)borate), X=O, S, R=aryl. Syntheses of Mo(4+) and (5+) complexes of two pterin-dithiolene derivatives as both oxo and sulfido compounds, and improved syntheses for pterinyl alkynes and [Et(4)N][Tp(*)Mo(IV)(S)S(4)] reagents are described. Characterization methods include electrospray ionization mass spectrometry, electrochemistry, infrared spectroscopy, electron paramagnetic resonance and magnetic circular dichroism. Cyclic voltammetry reveals that the Mo(5+/4+) reduction potential is intermediate between that for dithiolenes with electron-withdrawing substituents and simple dithiolates chelates. Electron paramagnetic resonance and magnetic circular dichroism of Mo(5+) complexes where X=O, R=aryl indicates that the molybdenum environment in the new models is electronically similar to that in Tp(*)MoO(benzenedithiolate).
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Base de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
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Pteridinas
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Coenzimas
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Metaloproteínas
Idioma:
En
Revista:
J Inorg Biochem
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos